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Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents

2010; Elsevier BV; Volume: 20; Issue: 17 Linguagem: Inglês

10.1016/j.bmcl.2010.06.147

1464-3405

Ähmed Kamal, Jhansi Reddy, M. Janaki Ramaiah, E. Vijaya Bharathi, D. Dastagiri, M. Kashi Reddy, S. N. C. V. L. Pushpavalli, Manika Pal‐Bhadra,

Synthesis and Reactivity of Heterocycles

A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the characteristic features of apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP.