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ISACGH: a web-based environment for the analysis of Array CGH and gene expression which includes functional profiling

2007; Oxford University Press; Volume: 35; Issue: Web Server Linguagem: Inglês

10.1093/nar/gkm257

1362-4962

Lucía Conde, David Montaner, J. Burguet–Castell, Joaquín Tárraga, Ignacio Medina, Fátima Al‐Shahrour, Joaquı́n Dopazo,

Genomics and Phylogenetic Studies

We present the ISACGH, a web-based system that allows for the combination of genomic data with gene expression values and provides different options for functional profiling of the regions found. Several visualization options offer a convenient representation of the results. Different efficient methods for accurate estimation of genomic copy number from array-CGH hybridization data have been included in the program. Moreover, the connection to the gene expression analysis package GEPAS allows the use of different facilities for data pre-processing and analysis. A DAS server allows exporting the results to the Ensembl viewer where contextual genomic information can be obtained. The program is freely available at: http://isacgh.bioinfo.cipf.es or within http://www.gepas.org.