Elimination Kinetics of Cefotaxime and Desacetyl Cefotaxime in Patients with Renal Insufficiency and during Hemodialysis
1983; Karger Publishers; Volume: 29; Issue: 1 Linguagem: Inglês
10.1159/000238166
ISSN1421-9794
AutoresMitsuo Ohkawa, Akira Okasho, Isamu Motoi, Shuji Tokunaga, Ryochu Shoda, Shoichi Kawaguchi, M Sawaki, Masayoshi Shimamura, Shoji Hirano, Kyoichi Kuroda, Shoji Awazu,
Tópico(s)Pneumonia and Respiratory Infections
ResumoThe pharmacokinetics of cefotaxime, a new semi-synthetic cephalosporin for injection, was studied in 30 subjects with various degrees of renal function after a single 1-gram intramuscular injection. Serum and urinary concentrations of cefotaxime and desacetyl cefotaxime were determined by high pressure liquid chromatography. The pharmacokinetic parameters of cefotaxime were obtained using a one-compartment open model. The mean serum half-life of the parent compound (cefotaxime), 0.87 h in normal subjects, was prolonged to 2.35 h in hemodialysis patients. There was a significant linear correlation between the elimination rate constant of cefotaxime and creatinine clearance. The mean cumulative urinary recovery of the administered dose in the 24-hour urine was 51.7% as cefotaxime and 25.6% as desacetyl cefotaxime in normal subjects.
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