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Mechanism of vitamin D action and its regulation

1998; Elsevier BV; Volume: 32; Issue: 4 Linguagem: Inglês

10.1053/ajkd.1998.v32.pm9808140

1523-6838

Dusso As, AJ Brown,

Growth Hormone and Insulin-like Growth Factors

Most of the biological actions of 1,25(OH)2D3, the hormonal form of vitamin D, are mediated by the vitamin D receptor (VDR), a member of the steroid/thyroid receptor superfamily. The VDR functions as a ligand- induced transcription factor regulating the rate of expression of genes involved not only in the control of calcium homeostasis and bone remodeling, but also in immunomodulation, the control of hormone secretion, Inhibition of cell growth, and induction of cell differentiation. This section discusses the molecular mechanisms involved in the transcriptional control of gene expression by 1,25(OH)2D3. (Am J Kidney Dis 1998 Oct;32(2 Suppl 2):S13-24)