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Antioxidant Effects in the Quinone Fraction from Auxemma oncocalyx TAUB.

2003; Pharmaceutical Society of Japan; Volume: 26; Issue: 5 Linguagem: Inglês

10.1248/bpb.26.595

1347-5215

Maria Augusta Drago Ferreira, Osmar Del Rio Holanda Nunes, Luzia Kalyne Almeida Moreira Leal, Otília Deusdênia Loiola Pessoa, Telma L. G. Lemos, Glauce Socorro de Barros Viana,

Phenothiazines and Benzothiazines Synthesis and Activities

In previous studies in vitro we showed that the quinone fraction (QF) from the heartwood of Auxemma oncocalyx TAUB. presented antiplatelet and antioxidant activities. In the present work, the QF antioxidant property was evaluated in models of CCl4-induced hepatotoxicity in rats, and prolongation of pentobarbital-induced sleeping time in mice. Our results showed that levels of plasma glutamate-pyruvate-transaminase (GPT), as well as glutamate-oxalate-transaminase (GOT), were increased by the administration of CCl4. On the other hand, only GPT levels were reduced by the QF treatment. Pentobarbital sleeping time was prolonged by the administration of CCl4 and reduced by the QF treatment. Moreover, QF did not alter the pentobarbital-induced sleeping time. In conclusion, we showed that QF, represented mainly by oncocalyxone A, has hepatoprotective activity, and this effect is at least in part due to the antioxidant activity of this quinone.