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New stilbene dimers against amyloid fibril formation

2009; Elsevier BV; Volume: 20; Issue: 11 Linguagem: Inglês

10.1016/j.bmcl.2009.09.074

1464-3405

Céline Rivière, Yorgos Papastamoulis, Pierre‐Yves Fortin, Nicolas Delchier, Soahary Andriamanarivo, Pierre Waffo‐Téguo, Gilbert Deccaux Wabo Fotso Kapche, H. Amira-Guebalia, Jean‐Claude Delaunay, Jean‐Michel Mérillon, Tristan Richard, Jean‐Pierre Monti,

Natural product bioactivities and synthesis

Twenty stilbene derivatives and moracin M extracted from natural products were tested against amyloid-beta peptide (Abeta) aggregation. Results of stilbene monomer derivatives indicated that interaction with resveratrol and piceid was specific. Concerning oligomers, scirpusin A and epsilon-viniferin glucoside demonstrated a strong inhibition of the aggregation process.