Quinine-Induced Hypoglycemia
1993; American College of Physicians; Volume: 119; Issue: 3 Linguagem: Inglês
10.7326/0003-4819-119-3-199308010-00007
ISSN1539-3704
AutoresPaul J. Limburg, Harry L. Katz, C. S. Grant,
Tópico(s)Poisoning and overdose treatments
ResumoBrief Reports1 August 1993Quinine-Induced HypoglycemiaP. J. Limburg, MD, H. Katz, MD, C. S. Grant, MD, and F. J. Service, MDP. J. Limburg, MDFrom the Mayo Clinic and Mayo Medical School, Rochester, Minnesota.Search for more papers by this author, H. Katz, MDFrom the Mayo Clinic and Mayo Medical School, Rochester, Minnesota.Search for more papers by this author, C. S. Grant, MDFrom the Mayo Clinic and Mayo Medical School, Rochester, Minnesota.Search for more papers by this author, and F. J. Service, MDFrom the Mayo Clinic and Mayo Medical School, Rochester, Minnesota.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-119-3-199308010-00007 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Table. SI Units and Drug Although quinine has been repeatedly implicated in the genesis of hypoglycemia observed in severe falciparum malaria [1-4], no well-documented cases of quinine-mediated hypoglycemia have been reported in healthy persons. We describe a patient who had repeated episodes of symptomatic hypoglycemia during quinine therapy for leg cramps.Case ReportA 66-year-old white man had a 2.5-year history of episodic intense diaphoresis, tremulousness, and weakness without confusion or unconsciousness, relieved within 10 minutes of eating a candy bar. Episodes occurred just before or about 2 hours after meals. Because of a fasting ...References1. White NJ, Warrell DA, Chanthavanich P, Looareesuwan S, Warrell MJ, Krishna S, et al. Severe hypoglycemia and hyperinsulinemia in falciparum malaria. N Engl J Med. 1983; 309:61-6. Google Scholar2. Okitolonda W, Delacollette C, Malengreau M, Henquin JC. High incidence of hypoglycaemia in African patients treated with intravenous quinine for severe malaria. Br Med J. (Clin Res Ed). 1987; 295:716-8. Google Scholar3. Arya TV, Prasad RN, Bhandari S, Awasthi R. Spontaneous and quinine induced hypoglycaemia in severe falciparum malaria. Trop Geogr Med. 1989; 41:73-5. Google Scholar4. Das BS, Satpathy SK, Mohanty D, Mohanty S, Mishra SK, Satapathy PC, et al. Hypoglycaemia in severe falciparum malaria. Trans R Soc Trop Med Hyg. 1988; 82:197-201. Google Scholar5. Kadish AH, Litle RL, Sternberg JC. A new and rapid method for the determination of glucose by measurement of rate of oxygen consumption. Clin Chem. 1968; 14:116. Google Scholar6. Service FJ, O'Brien PC, Kao PC, Young WF Jr. C-peptide suppression test: effects of gender, age, and body mass index; implications for the diagnosis of insulinoma. J Clin Endocrinol Metab. 1992; 74: 204-10. Google Scholar7. Harats N, Ackerman Z, Shalit M. Quinine-related hypoglycemia (Letter). N Engl J Med. 1984; 310:1331. Google Scholar8. Jones RG, Sue-Ling HM, Kear C, Wiles PG, Quirke P. Severe symptomatic hypoglycaemia due to quinine therapy. J R Soc Med. 1986; 79:426-8. Google Scholar9. Henquin JC, Horemans B, Nenquin M, Verniers J, Lambert AE. Quinine-induced modifications of insulin release and glucose metabolism by isolated pancreatic islets. FEBS Lett. 1975; 57:280-4. Google Scholar10. Service FJ, O'Brien PC, McMahon MM, Kao PC. C-peptide during the prolonged fast in insulinoma. J Clin Endocrinol Metab. 1993; 76: 655-9. Google Scholar Author, Article, and Disclosure InformationAffiliations: From the Mayo Clinic and Mayo Medical School, Rochester, Minnesota.Corresponding Author: F. John Service, MD, Division of Endocrinology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByAcute chloroquine and hydroxychloroquine toxicity: A review for emergency cliniciansQuinineInsulinomaHypoglycemia in the Nondiabetic PatientDrug-Induced HypoglycaemiaDrug-induced endocrine disorders in the intensive care unitPrescription pattern of anti—malarial drugs in a tertiary care hospitalOral quinine-induced hypoglycaemic seizuresQuinine-associated hypoglycaemia causing diabetesAre There Alternatives to the Use of Quinine to Treat Nocturnal Leg Cramps?Hypoglycemia: An Endocrine EmergencyHypoglycemiaEl agua tónica como causa de hipoglucemia grave en un individuo no diabéticoNeonatal BabesiosisAntimalarial Drug ToxicityPharmacological Agents That Directly Modulate Insulin SecretionQuinine Allergy Causing Acute Severe Systemic Illness: Report of 4 Patients Manifesting Multiple Hematologic, Renal, and Hepatic AbnormalitiesConsensual Treatment of Plasmodium falciparum Malaria Does not Lead to Adequate Quinine Blood ConcentrationsDesensitization of insulin secretory response to imidazolines, tolbutamide, and quinineQuinine Overdose: Hypoglycemia Potentiated by Age and AlcoholEffets indésirables des antimalariques, cardiotoxicité exclueCLASSIFICATION OF HYPOGLYCEMIC DISORDERSShould People with Nocturnal Leg Cramps Drink Tonic Water and Bitter Lemon?InsulinomaHYPOGLYCEMIAInsulinomaHypoglycemic DisordersHypoglycemia in Dialysis PatientsAntiprotozoal drugsQuinine 1 August 1993Volume 119, Issue 3Page: 218-219KeywordsAttentionBlood plasmaGlucoseHemoglobinHypoglycemiaInsulinInsulinomaMalariaMusclesQuinine Issue Published: 1 August 1993 CopyrightCopyright © 1993 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Referência(s)