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BIBTEX RIS

EFFECTS OF AMG 145, A FULLY HUMAN MONOCLONAL ANTIBODY AGAINST PCSK9, ON LOW-DENSITY LIPOPROTEIN CHOLESTEROL IN SUBJECTS TAKING STATINS: A PHASE 1, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, ASCENDING MULTIPLE-DOSE STUDY

2012; Elsevier BV; Volume: 59; Issue: 13 Linguagem: Inglês

10.1016/s0735-1097(12)61380-1

ISSN

1558-3597

Autores

Clapton Dias, Adam J. Shaywitz, Blaire Cooke, Stephen Uy, Maurice G. Emery, John P. Gibbs, Caroline Crispino, Karen Smirnakis, Brian P. Smith, Bing Gao, Scott M. Wasserman, Evan A. Stein,

Tópico(s)

Computational Drug Discovery Methods

Resumo

Proprotein convertase subtilisin/kexin type 9 (PCSK9) downregulates surface expression of the low density lipoprotein (LDL) receptor (LDL-R), increasing circulating LDL cholesterol (LDL-C). Statins increase LDL-R and PCSK9 levels. AMG 145, a fully human monoclonal antibody against PCSK9, has been

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