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Activity of NAD-kinase of nymph Triatoma infestants upon treatment with DDT and other compounds

1964; Pergamon Press; Volume: 11; Issue: 3 Linguagem: Inglês

10.1016/0010-406x(64)90110-0

1879-3029

Jovita Ilevicky, María Luisa Dinamarca, Manuel R. Agosín,

Coenzyme Q10 studies and effects

1. DDT and various compounds icnrease the in vivo concentration of NAD-kinase in T. infestants nymphs. On the other hand, other compounds are inhibitory. The effect of DDt is observed only with internal concentrations of approximately 15 μg, while lower concentrations inhibit the enzyme. NAD-kinase is induced more rapidly with DDD and DDT. The inductive effect is not permanent since, upon removal of DDT, NAD-kinase activity decreases. 2. The activation of NAD-kinase by DDT and some analogs as well as its inhibition by other compounds correlate with Hammett's Sigma values, yielding a monophasic plot. 3. The increase in NAD-kinase resulting from DDt treatment is interpreted as an inductive phenomenon rather than simply an enzyme activation. 4. It is postulated that DDT treatment induced a special pattern of enzyme activity in T. infestants which changes the physiological capacities of the insects. These changes may be important in relation to DDT-resistance.