Synthesis of a radiotracer for studying dopamine uptake sites in vivo using PET: 2β‐carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐ 11 C‐methyl]tropane ([ 11 C]CFT or [ 11 C]WIN‐35,428)
1993; Wiley; Volume: 33; Issue: 2 Linguagem: Inglês
10.1002/jlcr.2580330209
ISSN1099-1344
AutoresRobert F. Dannals, John L. Neumeyer, Richard A. Milius, Hayden T. Ravert, Alan A. Wilson, Henry N. Wagner,
Tópico(s)Biotin and Related Studies
ResumoAbstract 2β‐Carbomethoxy‐3β‐(4‐fluorophenyl)‐[N‐ 11 C‐methyl]tropane, a potent inhibitor of dopamine transport, was prepared by N‐methylation of the appropriate nor‐methyl precursor in DMF with [ 11 C]iodomethane. After derivatization of unreacted precursor with a long chain acyl halide, the radiotracer was purified using reversed phase semipreparative HPLC. The average specific activity was 3065 mCi/μmole (calculated at the end‐of‐synthesis; EOS). The average time of synthesis including formulation was approximately 21 minutes.
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