Immunosuppressive diacetylenes, ceramides and cerebrosides from Hydrocotyle leucocephala
2006; Elsevier BV; Volume: 67; Issue: 11 Linguagem: Inglês
10.1016/j.phytochem.2006.03.004
ISSN1873-3700
AutoresFreddy A. Ramos, Yoshihisa Takaishi, Kazuyoshi Kawazoe, Coralia Osorio, Carmenza Duque, Ricardo Acuña, Yoshinori Fujimoto, Mitsunobu Sato, Masato Okamoto, Tetsuya Oshikawa, Sharif Ahmed,
Tópico(s)Essential Oils and Antimicrobial Activity
ResumoThree C-17 diacetylenic compounds (1–3), one monoterpenoid (4), seven ceramides (leucoceramides A–G, 5a–g), six cerebrosides (leucocerebrosides A–F, 6a–f) and nine known compounds were isolated from the methanolic extract of Hydrocotyle leucocephala. Their structures were established by spectroscopic methods. The isolated compounds 1–3, 5a–g, 6a–f and 7 were shown to be active in the lipopolysaccharide (LPS) induced cytokine production assay for IL-10, IL-12, and TNF-α.
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