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An IMP-Reset gate-based reusable and self-powered “smart” logic aptasensor on a microfluidic biofuel cell

2010; Royal Society of Chemistry; Volume: 10; Issue: 21 Linguagem: Inglês

10.1039/c0lc00009d

1473-0197

Ming Zhou, Chaogui Chen, Yan Du, Bingling Li, Dan Wen, Shaojun Dong, Erkang Wang,

Biosensors and Analytical Detection

The development of microfluidic devices has been spurred by the desire to produce low-cost point-of-care diagnostics and environmental monitoring devices. By combining the adaptive behavior of microfluidic biofuel cells (micro-BFCs) self-regulating the power release with aptamer IMP logic, we constructed a novel IMP-Reset gate-based reusable and self-powered on-chip aptasensor, which can be used to logically determine the presence of one specific target in the absence of another target in complex physiological samples (such as human serum) in a single test.