Saikosaponin derivatives from Bupleurum wenchuanense
1993; Elsevier BV; Volume: 33; Issue: 5 Linguagem: Inglês
10.1016/0031-9422(93)85049-w
ISSN1873-3700
AutoresSi‐Qi Luo, Long‐Ze Lin, Geoffrey A. Cordell,
Tópico(s)Sesquiterpenes and Asteraceae Studies
ResumoFrom the roots of Bupleurum wenchuanense 14 derivatives of saikosaponin were isolated and identified as 2″-O-β-d-xylopyranosylsaikosaponin b2, 3″,6″-O,O-diacetylsaikosaponin b2, 2″-O-β-d-glucopyranosylsaikosaponin b2, saikosaponin b2, 6″-O-acetylsaikosaponin b2, saikosaponin d, 2″-O-acetylsaikosaponin d, 3″-O-acetylsaikosaponin d, 6″-O-acetylsaikosaponin d, 16-epichikusaikoside, prosaikogenin G, saikosaponin a, 2″-O-acetylsaikosaponin a and 3″-O-acetylsaikosaponin a. The first two compounds are new derivatives of saikosaponin and this is the first isolation of prosaikogenin G from a plant. Their complete 1H and 13C NMR assignments were made by using a combination of 2D NMR techniques (DQF-COSY, HOHAHA, ROESY, HETCOR, HMQC and HMBC). Some of the compounds showed cytotoxic activity against the P-388 cell line.
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