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Synthetic organic compounds with potential for bacterial biofilm inhibition, a path for the identification of compounds interfering with quorum sensing

2013; Elsevier BV; Volume: 42; Issue: 6 Linguagem: Inglês

10.1016/j.ijantimicag.2013.07.006

1872-7913

Andréa L. Pimenta, Louise Domeneghini Chiaradia-Delatorre, Alessandra Mascarello, Karen Andrinéia de Oliveira, Paulo César Leal, Rosendo Augusto Yunes, Claudia Aguiar, Carla I. Tasca, R.J. Nunes, Artur Smânia,

Antibiotic Resistance in Bacteria

New unconventional approaches to the development of antimicrobial drugs must target inhibition of infection stages leading to host colonisation or virulence itself, rather than bacterial viability. Amongst the most promising unconventional targets for the development of new antimicrobial drugs is bacterial adherence and biofilm formation as well as their control system, the quorum-sensing (QS) system, a mechanism of communication used to co-ordinate bacterial activities. Here we describe the evaluation of synthetic organic compounds as bacterial biofilm inhibitors against a panel of clinically relevant Gram-positive and Gram-negative bacterial strains. This approach has successfully allowed the identification of five compounds (GEt, GHex, GOctad, G19 and C33) active not only against bacterial biofilms but also displaying potential to be used as antagonists and/or inhibitors of bacterial QS.