Design of Sequence‐Specific DNA‐Binding Ligands
1997; Wiley; Volume: 3; Issue: 4 Linguagem: Inglês
10.1002/chem.19970030404
ISSN1521-3765
Autores Tópico(s)RNA Interference and Gene Delivery
ResumoAbstract Double‐stranded DNA can be viewed as a multifunctional, modular receptor that can be read sequence‐selectively in a digital way (base pair per base pair) by a complementary, similarly modular ligand. This principle has been exploited in several approaches to design sequence‐specific DNA‐binding ligands, such as triplex‐forming oligonucleotides, peptide nucleic acids and minor groove binding polyamides.
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