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The Application of Nonaqueous Titrimetry to the Determinations of Cholic, Desoxycholic, and Dehydrocholic acids*

1955; Elsevier BV; Volume: 44; Issue: 9 Linguagem: Inglês

10.1002/jps.3030440904

1930-2304

R Crisafio, L.G. Chatten,

Metabolomics and Mass Spectrometry Studies

Cholic, desoxycholic, and dehydrocholic acids can be titrated visually in either benzene‐methanol or N,N‐dimethylformamide‐chloroform as solvents, thymol blue as the indicator and either potassium methoxide solution or alcoholic potassium hydroxide as the titrant. Evidence is quoted to indicate that dissolving potassium hydroxide in methanol leads to the formation of potassium methoxide which will behave in a manner similar to the potassium methoxide formed by reacting metallic potassium with methanol.