Neurophysiologic Changes in Lumbar Nerve Root Inflammation in the Rat After Treatment With Cytokine Inhibitors
1996; Lippincott Williams & Wilkins; Volume: 21; Issue: 8 Linguagem: Inglês
10.1097/00007632-199604150-00005
ISSN1528-1159
AutoresPeter Wehling, S. Cleveland, Kurt Heininger, Klaus-Peter Schulitz, J. Reinecke, C H Evans,
Tópico(s)Dermatology and Skin Diseases
ResumoStudy Design The present study was designed to evaluate the effect of cytokine inhibitors in experimental allergic radicultis. Objective Evaluation of the effect of cytokine inhibitors in experimental allergic radicultis. Summary of Background Data A number of cytokines are known to be involved in hyperalgesia and may play a role in radicultis. Corticosteroids and other cytokine inhibitors antagonize their effects. Methods Experimental allergic radiculitis was induced in rats by injection of bovine myelin from the peripheral nervous system. The sham group subsequently received saline injections; the treatment groups received either prednisolone or interleukin-1 receptor antagonist. Treatment effect was assessed on the basis of motor performance and neurophysiologic parameters. Results Treatment ameliorated the symptoms of experimental allergic radiculitis. Prednisolone appeared to be somewhat more effective than interleukin-1 receptor antagonist. Conclusions Because interleukin-1 receptor antagonist specifically blocks the effects of interleukin-1 at its receptors, the present results imply that interleukin-1 is a causal factor in the model of experimental radiculitis used. Its specificity and apparent lack of side effects make interleukin-1 receptor antagonist an attractive candidate treatment for the human disease.
Referência(s)