Mapping drug-induced changes in cerebral by Multiple Gradient Recalled Echo functional MRI
1996; Elsevier BV; Volume: 14; Issue: 5 Linguagem: Inglês
10.1016/0730-725x(95)02100-8
ISSN1873-5894
AutoresQ. Chen, Anders H. Andersen, Z. Zhang, Aliza Ovadia, Don M. Gash, Malcolm J. Avison,
Tópico(s)Functional Brain Connectivity Studies
ResumoA Multiple Gradient Recalled Echo MRI sequence was used to map spatial and temporal changes in the rate of MR signal decay (R2∗) in response to L-3,4-dihydroxyphenylalanine (levodopa) in the striatal dopaminergic system of a rhesus monkey unilaterally lesioned with 4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP). R2∗ decreased significantly in the right (dopamine depleted) putamen and caudate following levodopa. More focal areas of smaller R2∗ decline were also observed in these structures in the left hemisphere. The observed spatial and temporal patterns of R2∗ change support the view that the method is monitoring changes in neural activity.
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