Growth of mouse encephalomyelitis virus in Earle's L cells
1959; Elsevier BV; Volume: 9; Issue: 1 Linguagem: Inglês
10.1016/0042-6822(59)90103-5
ISSN1096-0341
AutoresClaudia Henry, Richard M. Franklin,
Tópico(s)Herpesvirus Infections and Treatments
ResumoThe growth of mouse encephalomyelitis (ME) virus was studied on monolayers of Earle's L cells. Cell-associated virus (CAV) was 60 to 1000 times higher in titer than released virus and could not be neutralized with ME antiserum. This indicates that the infectious particle is completed internally. Fluorescent antibody to ME virus showed that the virus antigen is formed in the cytoplasm. Concentration of viral antigen in peripheral nodules could be correlated with release of virus from infected cells.
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