Kinetics of In Vitro Lysozyme Deposition on Silicone Hydrogel, PMMA, and FDA Groups I, II, and IV Contact Lens Materials
2006; Taylor & Francis; Volume: 31; Issue: 10 Linguagem: Inglês
10.1080/02713680600888799
ISSN1460-2202
AutoresLakshman N. Subbaraman, Mary-Ann Glasier, Michelle Senchyna, Heather Sheardown, Lyndon Jones,
Tópico(s)Advancements in Transdermal Drug Delivery
ResumoWe sought to compare the kinetics of in vitro lysozyme deposition on silicone hydrogel (SH), polymethyl methacrylate (PMMA), and FDA groups I, II, and IV contact lenses. Lenses were incubated in 125I-labeled lysozyme for time periods ranging from 1 hr to 28 days, and radioactive counts were determined. SH lenses and PMMA deposited less lysozyme than conventional hydrogel lenses (p < 0.05). Lysozyme accumulation on group IV lenses reached a maximum on the seventh day and then plateaued, whereas on groups I, II, and SH lenses, deposition continued to increase across all time periods, reiterating that kinetics of lysozyme deposition is highly material dependent.
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