Se 75 -Selenomethionine for Visualization of the Pancreas by Isotope Scanning
1962; Radiological Society of North America; Volume: 78; Issue: 6 Linguagem: Inglês
10.1148/78.6.974
ISSN1527-1315
AutoresMonte Blau, Merrill A. Bender,
Tópico(s)Selenium in Biological Systems
ResumoHomeRadiologyVol. 78, No. 6 PreviousNext Work in ProgressSe75-Selenomethionine for Visualization of the Pancreas by Isotope ScanningMonte Blau, Merrill A. BenderMonte Blau, Merrill A. BenderMonte BlauMerrill A. BenderPublished Online:Jun 1 1962https://doi.org/10.1148/78.6.974MoreSectionsPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookXLinked In AbstractWith recent advances in instrumentation (1) and the development of new localizing materials, isotope scanning has been applied to the visualization of lesions of the thyroid, kidneys, brain, liver, spleen, and bone. The addition of the pancreas to this growing list has awaited the development of a suitably labeled pancreas-specific compound. We have previously reported (2) animal distribution studies of a new agent, Se75-selenomethionine, with sufficient pancreas specificity to be useful for scanning. The present report deals with the clinical applications of this compound.The pancreas uptake of amino acids has been recognized for some time (3). This uptake is a reflection of the rapid rate of synthesis of the digestive enzymes. From 5 to 10 per cent of most amino acids are found in the pancreas within an hour after administration. Unfortunately none of the elements in the structure of amino acids (C, H, N, O, and S) have isotopes with properties suitable for scanning. Externally labeled amino acids (e.g., I131-iodotyrosine), because of their inability to take part in protein synthesis, show no pancreatic uptake. The chemical similarity of selenium and sulfur is so close that the substitution of Se75 for sulfur within a methionine molecule results in an analog which has all the properties of amino acids (2, 4), including incorporation into proteins. The physical properties of Se75 (half-life, 128 days; principal γ ray, 0.27 Mev) are well suited to scanning.Using Se75-selenomethionine prepared by yeast biosynthesis (5), we have scanned more than 50 patients. Since the pancreatic tissue itself is not labeled, a protocol must be used which favors enzyme synthesis within the pancreas but avoids any stimulus which would cause pancreatic secretion. In addition, it appears that prolonged food deprivation (overnight or longer) favors uptake in the liver. We have temporarily adopted the following procedure: Three to four hours following a high protein break fast, the pancreas is stimulated to empty by a dose of mixed secretin and pancreozymin (Cecekin Vitrum); one hour later, 3 to 3.5 rnicrocuries/kilogram of Se75-selenomethionine are given intravenously, and scanning is started one half hour after injection. We have been able to visualize the pancreas in about two-thirds of the patients scanned. To date, no scans have been done on patients with known pancreatic disease. The estimated dose to the patient from this procedure is about 0.6 rad, total body, delivered over several months.In Figure 1 are reproduced two selected photoscans showing good pancreas visualization. The densities in the upper left hand corner represent the thick portions of the liver. It seems possible that space-occupying pancreatic lesions 2 cm. or more in diameter could be visualized as nonfunctioning areas of decreased uptake on scans of this type.Article HistoryPublished in print: June 1962 FiguresReferencesRelatedDetailsCited ByNext-Generation Nanobiosensor Devices for Point-Of-Care DiagnosticsPriyaSarkar, ShivaniKhatana, BimalenduMukherjee, JaiShukla, BiswajitDas, GorachandDutta2023Selenomethionine incorporation in proteins of individual mammalian cells determined with a genetically encoded fluorescent sensorRama A.Hussein, MarwaAhmed, NikitaKuldyushev, RolandSchönherr, Stefan H.Heinemann2022 | Free Radical Biology and Medicine, Vol. 192Indian Institute of Metals SeriesPrasad P.Phadnis2021Design of 99mTc-labeled zinc-chelating imaging probe for SPECT imaging of the pancreasVenkateswararaoEeda, AndriaHedrick, VibhuduttaAwasthi2021 | Bioorganic & Medicinal Chemistry Letters, Vol. 52Time of flight dual photon emission computed tomographyChih-ChiehChiang, Chun-ChaoChuang, Yu-ChingNi, Meei-LingJan, Keh-ShihChuang, Hsin-HonLin2020 | Scientific Reports, Vol. 10, No. 12015 4th International Conference on Advancements in Nuclear Instrumentation Measurement Methods and their Applications (ANIMMA)Chih-ChiehChiang, Hsin-HonLin, Chang-ShiunLin, Meei-LingJan, Keh-ShihChuang2015Gamma camera imaging for studying intestinal absorption and whole-body distribution of selenomethionineJan L.Madsen, KatarinaSjögreen-Gleisner, Dennis R.Elema, Lasse R.Søndergaard, PalleRasmussen, StefanFuglsang, MichaelLjungberg, MortenDamgaard2014 | British Journal of Nutrition, Vol. 111, No. 3Tricarbonyltechnetium(i) and tricarbonylrhenium(i) complexes of amino acids: crystal and molecular structure of a novel cyclic dimeric Re(CO)3-amino acid complex comprised of the OON donor atom set of the tridentate ligandDipak KumarNayak, Kamal KrishnaHalder, RinkuBaishya, TuhinadriSen, ParthaMitra, Mita ChatterjeeDebnath2013 | Dalton Transactions, Vol. 42, No. 37Selenium in human and animal nutrition: Resolved and unresolved issues. 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