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The bacteria Wolbachia in filariae, a biological Russian dolls’ system: new trends in antifilarial treatments

2010; EDP Sciences; Volume: 17; Issue: 2 Linguagem: Inglês

10.1051/parasite/2010172079

1776-1042

Coralie Martin, Laurent Gavotte,

Insect symbiosis and bacterial influences

Filarial nematode species can host Wolbachia bacterial endosymbionts. To understand the symbiosis, a higher level of complexity should be considered, taking in account the tripartite association between Wolbachia, filariae and mammals. This overview article discusses the biology of Wolbachia in filariae, including their distribution and phylogeny, mechanisms of action, inflammatory consequences on mammal host and biological control implications for filariases. Potential directions for future research are also discussed.