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Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype

2013; Elsevier BV; Volume: 121; Issue: 23 Linguagem: Inglês

10.1182/blood-2013-04-495390

1528-0020

Kyle M. Walsh, Adam J. de Smith, Anand P. Chokkalingam, Catherine Metayer, Gary V. Dahl, Ling‐I Hsu, Lisa F. Barcellos, Joseph L. Wiemels, Patricia A. Buffler,

Epigenetics and DNA Methylation

To the editor: A recent genome-wide association study of childhood acute lymphoblastic leukemia (ALL) by Xu et al[1][1] has identified a novel susceptibility locus encompassing BMI1 - PIP4K2A at chr10p12.31-12.2, bringing the number of known ALL risk loci to 5 (including ARID5B , IKZF1 , CEBPE, and