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Evaluation of beagle dogs as an animal model for bioavailability testing of cinnarizine capsules

1986; Elsevier BV; Volume: 29; Issue: 2-3 Linguagem: Inglês

10.1016/0378-5173(86)90109-2

1873-3476

Hiroyasu Ogata, Nobuo Aoyagi, Nahoko Kaniwa, Akira Ejima, Toshiyuki Kitaura, Toshimitsu Ohki, K Kitamura,

Analytical Methods in Pharmaceuticals

Abstract The bioavailability of cinnarizine, 25 mg, from two commercial capsules was determined in beagle dogs, and compared with that previously found in humans given the same preparations. The gastric pH of beagle dogs, which was determined 90 min after every oral dose of test preparation by using pH test paper inserted into the stomach through a catheter, ranged from pH 1.5 to pH 8.5 with wide inter- and intra-subject variations. The gastric acidity did not affect the bioavailability of cinnarizine from capsules in beagle dogs, although the human study had shown a distinct effect of gastric acidity on the bioavailability. The discrepancy between the results for cinnarizine bioavailability in humans and beagle dogs may be ascribable to a more variable gastric pH compared with humans. In conclusion, beagle dogs cannot be used as an animal model for predicting the human bioavailability of cinnarizine, since they do not reflect the gastric acidity dependency that is observed in humans.