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BIBTEX RIS

Correlação entre a cistatina C sérica e marcadores de aterosclerose subclínica em pacientes hipertensos

2012; Sociedade Brasileira de Cardiologia (SBC); Volume: 99; Issue: 4 Linguagem: Inglês

10.1590/s0066-782x2012005000083

ISSN

1678-4170

Autores

Francisco das Chagas Monteiro, Pedro Antônio Muniz Ferreira, José Aldemir Teixeira Nunes, Cacionor Pereira da Cunha Júnior, Ronald Lopes Brito, João Henrique Almeida Costa, José Ribamar Lima, Joyce Santos Lages, Natalino Salgado Filho, Valter Correia de Lima,

Tópico(s)

Blood Pressure and Hypertension Studies

Resumo

Serum cystatin C (s-CC), an endogenous marker of kidney function, has also been proposed as a cardiovascular risk marker. However, it is unknown whether it is a direct marker of atherosclerosis, independently of kidney function.The aim of this study was to correlate s-CC with two surrogate markers of subclinical atherosclerosis.This is a cross-sectional study involving 103 middle-aged (57.49 ± 11.7 years) hypertensive outpatients, being 60 female (58.25%), most with preserved kidney function. S-CC was correlated with carotid intima media thickness (IMT) and flow-mediated dilation of brachial artery (FMD), both assessed by ultrasound, as well as with measured creatinine clearance and established cardiovascular risk factors.S-CC was neither significantly correlated with IMT (r = -0.024; p = 0.84) nor with FMD (r = -0.050 and p = 0.687) and no significant association was observed with conventional risk factors and inflammatory markers. In univariate analysis, s-CC was correlated with measured creatinine clearance (r = -0,498; p < 0,001), age (r = 0,408; p < 0,001), microalbuminuria (r = 0,291; p = 0,014), uric acid (r = 0,391; p < 0,001), ratio E/e' (r = 0,242; p = 0,049) and Framingham score (r = 0,359; p = 0,001). However, after multiple regression analysis, only the association with measured creatinine clearance remained significant (r = -0,491; p < 0,001).In middle-aged hypertensive outpatients, s-CC correlated with measured creatinine clearance, as expected, but no association was observed with markers of atherosclerosis neither with established cardiovascular risk factors.

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