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CO-LOCALIZATION OF ANDROGEN RECEPTOR WITH ESTROGEN RECEPTOR β IN THE LOWER URINARY TRACT OF THE MALE RAT

2001; Lippincott Williams & Wilkins; Volume: 166; Issue: 2 Linguagem: Inglês

10.1016/s0022-5347(05)66041-7

1527-3792

Saija Salmi, Risto Santti, Jan-Ακε Gustafsson, Sari Mäkelä,

Sexual Differentiation and Disorders

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Aug 2001CO-LOCALIZATION OF ANDROGEN RECEPTOR WITH ESTROGEN RECEPTOR β IN THE LOWER URINARY TRACT OF THE MALE RAT SAIJA SALMI, RISTO SANTTI, JAN-ÂKE GUSTAFSSON, and SARI MÁKELÁ SAIJA SALMISAIJA SALMI , RISTO SANTTIRISTO SANTTI , JAN-ÂKE GUSTAFSSONJAN-ÂKE GUSTAFSSON , and SARI MÁKELÁSARI MÁKELÁ View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)66041-7AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Androgens and estrogens influence voiding. In this study their target sites in the lower urinary tract of the male rat were identified. Materials and Methods: Cryosections of the bladder body, bladder neck, prostatic urethra, mid proximal urethra and prostatic autonomic ganglia of adult male rats were immunostained with specific estrogen receptor α, estrogen receptor β (ERβ) or androgen receptor (AR) antibodies. The sections were then examined under conventional, fluorescence or confocal fluorescence microscopy. Results: Co-expression of AR and ERβ in the urothelium, bladder smooth muscle cells, proximal urethra striated muscle cells and neurons in the autonomic ganglia of the prostatic plexus suggests that estrogen and androgen have direct effects in the lower urinary tract. Conclusions: The local interaction of AR and ERβ in the hormonal control of voiding is an intriguing possibility. References 1 : Autonomic innervation of the muscles in the wall of the bladder and proximal urethra of male rats. J Anat1979; 128: 873. Google Scholar 2 : Functional responses of different muscle types of the female rat urethra in vitro. Acta Physiol Scand1990; 140: 365. Google Scholar 3 : The physiology of the mammalian urinary outflow tract. Exp Physiol1999; 84: 215. Google Scholar 4 : Comparison of urinary bladder function in sexually mature and immature male and female rats. J Urol1990; 143: 1267. 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Google Scholar From the Institute of Biomedicine, University of Turku, Turku, Finland, and Department of Medical Nutrition and Unit for Preventive Nutrition, Karolinska Institute, Novum, Huddinge, Sweden© 2001 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byShiota M, Takeuchi A, Yokomizo A, Kashiwagi E, Tatsugami K, Kuroiwa K and Naito S (2012) Androgen Receptor Signaling Regulates Cell Growth and Vulnerability to Doxorubicin in Bladder CancerJournal of Urology, VOL. 188, NO. 1, (276-286), Online publication date: 1-Jul-2012.Banie L, Lin G, Ning H, Wang G, Lue T and Lin C (2008) Effects of Estrogen, Raloxifene and Levormeloxifene on α1A-Adrenergic Receptor ExpressionJournal of Urology, VOL. 180, NO. 5, (2241-2246), Online publication date: 1-Nov-2008.Thomas J, Oottamasathien S, Makari J, Honea L, Sharif-Afshar A, Wang Y, Adams C, Wills M, Bhowmick N, Adams M, Brock J, Hayward S, Matusik R and Pope J (2008) Temporal-Spatial Protein Expression in Bladder Tissue Derived From Embryonic Stem CellsJournal of Urology, VOL. 180, NO. 4S, (1784-1789), Online publication date: 1-Oct-2008.SHARIF-AFSHAR A, DONOHOE J, POPE J, ADAMS M, BROCK J and BHOWMICK N (2018) STROMAL HYPERPLASIA IN MALE BLADDERS UPON LOSS OF TRANSFORMING GROWTH FACTOR-β SIGNALING IN FIBROBLASTSJournal of Urology, VOL. 174, NO. 4 Part 2, (1704-1707), Online publication date: 1-Oct-2005.STRENG T, LEHTORANTA M, POUTANEN M, TALO A, LAMMINTAUSTA R and SANTTI R (2018) Developmental, Estrogen Induced Infravesical Obstruction is Reversible in Adult Male RodentsJournal of Urology, VOL. 168, NO. 5, (2263-2268), Online publication date: 1-Nov-2002.Streng T, Li X, Lehtoranta M, Mäkelä S, Poutanen M, Talo A, Rao Tekmal R and Santti R (2018) Infravesical Obstruction in Aromatase Over Expressing Transgenic Male Mice With Increased Ratio of Serum Estrogen-To-Androgen ConcentrationJournal of Urology, VOL. 168, NO. 1, (298-302), Online publication date: 1-Jul-2002. Volume 166Issue 2August 2001Page: 674-677 Advertisement Copyright & Permissions© 2001 by American Urological Association, Inc.Keywordsratsreceptorsreceptorsurinary tractestrogenandrogenMetrics Author Information SAIJA SALMI More articles by this author RISTO SANTTI More articles by this author JAN-ÂKE GUSTAFSSON Financial interest and/or other relationship with KaroBio AB. More articles by this author SARI MÁKELÁ More articles by this author Expand All Advertisement PDF downloadLoading ...