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Effect of Long-term Use of Moisturizer on Skin Hydration, Barrier Function and Susceptibility to Irritants

1999; Soc for Publication of Acta Dermato-Venereologica; Volume: 79; Issue: 1 Linguagem: Inglês

10.1080/000155599750011705

1651-2057

Snjólaug Sveinsdóttir Elisabeth Held,

Contact Dermatitis and Allergies

Moisturizers are often used in the prevention and treatment of irritant contact dermatitis.The present study was to determine whether long-term daily use of a moisturizer on normal skin would a¡ect skin barrier function, hydration state, or susceptibility to sodium lauryl sulphate.Healthy volunteers used a moisturizer on one forearm 3 times daily for 4 weeks.The other forearm served as a control.Afterwards both forearms were challenged with a patch-test of sodium lauryl sulphate.Skin barrier function was evaluated by measuring trans-epidermal water loss and skin hydration by measuring electrical capacitance.Electrical capacitance was signi¢cantly increased on the treated arm during the treatment period.After challenge with sodium lauryl sulphate, transepidermal water loss was signi¢cantly higher on the arm treated with moisturizer than on the control arm.The results suggest that long-term treatment with moisturizers on normal skin may increase skin susceptibility to irritants.