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Biological activities of pisiferic acid and O-methylpisiferic acid.

1986; Oxford University Press; Volume: 50; Issue: 9 Linguagem: Inglês

10.1271/bbb1961.50.2405

1881-1280

Koji Kobayashi, Chikao Nishino,

Natural product bioactivities and synthesis

Since clinical infection by Gram-negative bacteria has becomea serious problem recently, Gram-negative bacteria {Proteus vulgaris, P. morganii and Pseudomonas aeruginosa) were selected as test organisms for our first bioassay in a search for antibiotics against Gram-negative bacteria.In this study, a plant belonging to the Cupressaceae, Chamaecyparis pisifera Endl.var.plumosa Beissn.[Shinobuhiba in Japanese, an artificial variety of C. pisifera Endl.(Sawara in Japanese)], was employed as a natural source of such antibiotics.Because the methanol extract of leaves and twigs of C.