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γ-lactones from Trichilia claussenii

1998; Elsevier BV; Volume: 48; Issue: 2 Linguagem: Inglês

10.1016/s0031-9422(97)01089-3

1873-3700

Mônica Tallarico Pupo, Paulo C. Vieira, João B. Fernandes, Maria Fátima das Graças Fernandes da Silva,

Natural product bioactivities and synthesis

Four new γ-lactones: (2R,3S, 4S)-3-hydroxy-4-methyl-2-(13′-phenyl-1′-n-tridecyl)-butanolide, (2R,3S,4S)-3-hydroxy-4- methyl-2-(11′-phenyl-1′-n-undecyl)-butanolide, (2R,3S,4S)-3-hydroxy-4-methyl-2-(1′-n-hexadec-7′(Z)-enyl)-butanolide and (2R,3S,4S)-3-hydroxy-4-methyl-2-(1′-n-tetradecyl)-butanolide were isolated from T. claussenii. The absolute configuration of the isolated compounds was determined. The methanol extract of fruits of Trichilia claussenii yielded the new γ-lactones, (2R,3S, 4S)-3-hydroxy-4-methyl-2-(13′-phenyl-1′-n-tridecyl)-butanolide, (2R,3S,4S)-3-hydroxy-4-methyl-2-(11′-phenyl-1′-n-undecyl)-butanolide, (2R,3S, 4S)-3-hydroxy-4-methyl-2-(1′-n-hexadec-7′(Z)-enyl)butanolide and (2R,3S, 4S)-3-hydroxy-4-methyl-2-(1′-n-tetradecyl)-butanolide. The structures of the isolated compounds were determined on the basis of spectral analysis.