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No association between DGKH and bipolar disorder in a Scandinavian case–control sample

2009; Lippincott Williams & Wilkins; Volume: 19; Issue: 5 Linguagem: Inglês

10.1097/ypg.0b013e32832d302f

1473-5873

Martin Tesli, Anna K. Kähler, Bettina Kulle Andreassen, Thomas Werge, Ole Mors, Erling T. Mellerup, Pernille Koefoed, Ingrid Melle, Gunnar Morken, Katrine V. Wirgenes, Ole A. Andreassen, Srdjan Djurovic,

Pancreatic function and diabetes

Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.