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Accurate-mass instrumentation should not always be the first-and-only choice for MS in the drug metabolism environment

2011; Future Science Ltd; Volume: 3; Issue: 16 Linguagem: Inglês

10.4155/bio.11.169

1757-6199

Daniel J. Weston, Iain G. Beattie,

Microfluidic and Capillary Electrophoresis Applications

BioanalysisVol. 3, No. 16 EditorialAccurate-mass instrumentation should not always be the first-and-only choice for MS in the drug metabolism environmentDaniel J Weston & Iain G BeattieDaniel J Weston† Author for correspondenceClinical Pharmacology & DMPK, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK. & Iain G BeattieDiscovery DMPK, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UKPublished Online:30 Aug 2011https://doi.org/10.4155/bio.11.169AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: accurate-massalternativesdrug metabolismmetabolite characterizationmetabolites in safety testing (MIST)MSBibliography1 Ma S, Chowdhury SK, Alton KB. Application of mass spectrometry for metabolite identification. Curr. Drug Metab.7,503–523 (2006).Crossref, Medline, CAS, Google Scholar2 Makarov A. 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B876,182–190 (2008).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByAnalytical challenges for conducting rapid metabolism characterization for QIVIVEToxicology, Vol. 332Enhanced Analyte Detection Using In-Source Fragmentation of Field Asymmetric Waveform Ion Mobility Spectrometry-Selected Ions in Combination with Time-of-Flight Mass Spectrometry19 April 2012 | Analytical Chemistry, Vol. 84, No. 9Integrated quantitative and qualitative workflow for in vivo bioanalytical support in drug discovery using hybrid Q-TOF-MSAsoka Ranasinghe, Ragu Ramanathan, Mohammed Jemal, Celia J D'Arienzo, W Griffith Humphreys & Timothy V Olah12 March 2012 | Bioanalysis, Vol. 4, No. 5Using high-resolution quadrupole TOF technology in DMPK analysesJ Larry Campbell & JC Yves Le Blanc12 March 2012 | Bioanalysis, Vol. 4, No. 5Conference Report: High-resolution MS in drug discovery and development: current applications and future perspectivesDaniel J Weston & Lars Weidolf12 March 2012 | Bioanalysis, Vol. 4, No. 5 Vol. 3, No. 16 Follow us on social media for the latest updates Metrics Downloaded 348 times History Published online 30 August 2011 Published in print August 2011 Information© Future Science LtdKeywordsaccurate-massalternativesdrug metabolismmetabolite characterizationmetabolites in safety testing (MIST)MSFinancial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download