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Initial experience from a combination of systemic and regional chemotherapy in the treatment of patients with nonresectable cholangiocellular carcinoma in the liver

2005; Baishideng Publishing Group; Volume: 11; Issue: 8 Linguagem: Inglês

10.3748/wjg.v11.i8.1091

2219-2840

T. Kirchhoff,

Pancreatic and Hepatic Oncology Research

AIM:In nonresectable cholangiocellular carcinoma (CCC) therapeutic options are limited.Recently, systemic chemotherapy has shown response rates of up to 30%.Additional regional therapy of the arterially hyper vascularized hepatic tumors might represent a rational approach in an attempt to further improve response and palliation.Hence, a protocol combining transarterial chemoembolization and systemic chemotherapy was applied in patients with CCC limited to the liver. METHODS:Eight patients (6 women, 2 men, mean age 62 years) with nonresectable CCC received systemic chemotherapy (gemcitabine 1 000 mg/m 2 ) and additional transarterial chemoembolization procedures (50 mg/m² cisplatin, 50 mg/m² doxorubicin, up to 600 mg degradable starch microspheres).Clinical follow-up of patients, tumor markers, CT and ultrasound were performed to evaluate maximum response and toxicity. RESULTS:Both systemic and regional therapies were tolerated well; no severe toxicity (WHO III/IV) was encountered.Nausea and fever were the most commonly observed side effects.A progressive rarefication of the intrahepatic arteries limited the maximum number of chemoembolization procedures in 4 patients.A median of 2 chemoembolization cycles (range, 1-3) and a median of 6.5 gemcitabine cycles (range, 4-11) were administered.Complete responses were not achieved.As maximum response, partial responses were achieved in 3 cases, stable diseases in 5 cases.Two patients died from progressive disease after 9 and 10 mo.Six patients are still alive.The current median survival is 12 mo (range, 9-18); the median time to tumor progression is 7 mo (range, 3-18).Seven patients suffered from tumor-related symptoms prior to therapy, 3 of these experienced a treatment-related clinical relief.In one patient the tumor became resectable under therapy and was successfully removed after 10 mo. CONCLUSION:The present results indicate that a combination of systemic gemcitabine therapy and repeated regional chemoembolizations is well tolerated and may enhance the effect of palliation in a selected group of patients with intrahepatic nonresectable CCC.