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Effects of Various Levels of Dietary Lepidium Sativum L. Seeds in Rats

1999; World Scientific; Volume: 27; Issue: 03n04 Linguagem: Inglês

10.1142/s0192415x99000458

1793-6853

Safwaan Adam,

Complementary and Alternative Medicine Studies

A toxicity study was made on Lepidium sativum L. seeds used in Saudi traditional medicine for the treatment of various ailments. Lepidium sativum L. seed fed to Wistar albino rats at 2% (w/w) was non-toxic, Ten percent (w/w) was toxic but not fatal and 50% (w/w) of the diet for 6 weeks was lethal and caused depression in growth rate and entero-hepato-nephrotoxicity. Organ lesions accompanied by anemia and leukopenia were correlated with alterations in serum AST and ALT activities and concentrations of total protein, cholesterol, urea, and other serum constituents.