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The effect of polypeptide hormones on lipid monolayers. III. The effect of insulin, vasopressin, oxytocin, albumin, and prostaglandin E1 on the specific resistance to the evaporation of water through monomolecular films of monoöctadecyl phosphate, stearic acid, and stearyl alcohol

1972; Elsevier BV; Volume: 41; Issue: 1 Linguagem: Inglês

10.1016/0021-9797(72)90097-5

1095-7103

Marian S. Kafka, Charles Y.C. Pak,

Analytical Chemistry and Sensors

The hypothesis that insulin and vasopressin increase the permeability of cells to water and water-soluble substances by decreasing the adsorption of Ca2+ at the outer surface of the plasma membrane was tested in a model system. Changes in the specific resistance to the evaporation of water through monoöctadecyl phosphate (mOP) monolayers were compared with simultaneous changes in Ca2+ adsorption. Insulin and vasopressin cause a decrease in the resistance (or, alternatively, increase the transport of water) which can be accounted for only in part by the inhibition of Ca2+ adsorption. The action is specific for these hormones and dependent on interaction between the hormone and monolayer molecules.