Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae
2009; Multidisciplinary Digital Publishing Institute; Volume: 1; Issue: 2 Linguagem: Inglês
10.3390/toxins1020074
ISSN2072-6651
AutoresPerng‐Kuang Chang, Kenneth C. Ehrlich, Isao Fujii,
Tópico(s)Plant Pathogens and Fungal Diseases
ResumoCyclopiazonic acid (CPA) is an indole-tetramic acid neurotoxin produced by some of the same strains of A. flavus that produce aflatoxins and by some Aspergillus oryzae strains. Despite its discovery 40 years ago, few reviews of its toxicity and biosynthesis have been reported. This review examines what is currently known about the toxicity of CPA to animals and humans, both by itself or in combination with other mycotoxins. The review also discusses CPA biosynthesis and the genetic diversity of CPA production in A. flavus/oryzae populations.
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