Clinical, cytological and biological study of the intra-vaginal administration of oestriol (Ortho-Gynest®) in post-menopausal patients
1981; Elsevier BV; Volume: 3; Issue: 3-4 Linguagem: Inglês
10.1016/0378-5122(81)90034-7
ISSN1873-4111
AutoresS Wesel, J. Étienne, M.C. Lestienne,
Tópico(s)Estrogen and related hormone effects
ResumoAlthough some well-defined conditions require a replacement oestrogen therapy, local trophic disorders associated with the decrease of oestriol concentrations after surgical castration or menopause are corrected in a very satisfactory way by local oestrogen therapy. An initial treatment with 0.5 mg oestriol per day for 3 wk followed by a 4-wk maintenance therapy of 2 pessaries per week (2 x 0.5 mg) brings about a clinical cure and normalization of the maturation index in more than 95% of the 48 patients with surgical or natural menopause who received this treatment. The authors insist on the efficacy of this therapeutic approach.
Referência(s)