Long-term potentiation in the dentate gyrus is induced preferentially on the positive phase of θ-rhythm
1988; Elsevier BV; Volume: 439; Issue: 1-2 Linguagem: Inglês
10.1016/0006-8993(88)91499-0
ISSN1872-6240
AutoresConstantine Pavlides, Yoram J. Greenstein, Mark Grudman, Jonathan Winson,
Tópico(s)Neural dynamics and brain function
ResumoLong-term potentiation (LTP), a long lasting enhancement of synaptic efficacy is considered a model for learning and memory. In anesthetized rats, θ-rhythm was induced in the dentate gyrus by midbrain stimulation. Short trains of pulses were applied to the perforant pathway either at the peak of θ-rhythm or its trough. Trains applied at the peak of θ-rhythm induced LTP while trains applied at the trough produced a decrease of synaptic efficacy or had no effect. Thus, θ-rhythm may play a modulating role in the induction of LTP, suggesting a possible mnemonic function for the rhythm during the behaviors in which it occurs.
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