The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.
1980; Wiley; Volume: 9; Issue: 2 Linguagem: Inglês
10.1111/j.1365-2125.1980.tb05823.x
ISSN1365-2125
AutoresGG Skellern, BI Knight, CK Low, WD Alexander, DG McLarty, W J Kalk,
Tópico(s)Thyroid Disorders and Treatments
Resumo1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3-methyl-2-thiohydantoin in one patient. 3 Large interindividual differences were observed, especially within the carbimazole group. 4 Incomplete absorption of carbimazole could explain particular high apparent volumes of distribution and apparent clearances.
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