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Artigo Revisado por pares
BIBTEX RIS

Alkylation of succinates: Synthesis of Ro 32–3555

1998; Elsevier BV; Volume: 8; Issue: 2 Linguagem: Inglês

10.1016/s0960-894x(97)10179-2

ISSN

1464-3405

Autores

Kim F. McClure, Matthew Z. Axt,

Tópico(s)

Vanadium and Halogenation Chemistry

Resumo

A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32-3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives.

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