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Diagnosis of HAM/TSP based on CSF proviral HTLV-I DNA and HTLV-I antibody index

2001; Lippincott Williams & Wilkins; Volume: 57; Issue: 4 Linguagem: Inglês

10.1212/wnl.57.4.725

1526-632X

Marzia Puccioni‐Sohler, María Rios, Sílvia Maia Farias de Carvalho, R. R. Gonçalves, Carlos Oliveira, Rosalie Branco Corrêa, Sérgio A. P. Novis, Maria S. Pombo‐de‐Oliveira, Celso Bianco,

Vector-Borne Animal Diseases

The contribution of human T-cell lymphotropic virus (HTLV-I) DNA by PCR in CSF and the intrathecal synthesis of antibodies to HTLV-I by the antibody index (AI) to the diagnosis of HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) were evaluated. Cases of spastic paraparesis compatible with HAM/TSP had increased AI for HTLV-I (60/73) and HTLV-I proviral sequences in CSF (25/27). Among 27 patients with other neurologic diseases, three had increased AI and another three had positive HTLV-I DNA in CSF. Thus, the combination of PCR for proviral DNA and AI for HTLV-I in CSF provides consistent criteria for the diagnosis of HAM/TSP.