Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor
2013; Elsevier BV; Volume: 23; Issue: 24 Linguagem: Inglês
10.1016/j.bmcl.2013.10.018
ISSN1464-3405
AutoresHui Xiong, Melinda A. Foulk, Lisa Aschenbrenner, Jun Fan, Choi-Lai Tiong-Yip, Kenneth D. Johnson, Demetri T. Moustakas, Paul Fleming, Dean G. Brown, Minli Zhang, Douglas Ferguson, Dedong Wu, Qin Yu,
Tópico(s)Viral Infections and Immunology Research
ResumoTargeting viral polymerases has been a proven and attractive strategy for antiviral drug discovery. Herein we describe our effort in improving the antiviral activity and physical properties of a series of benzothienoazepine compounds as respiratory syncytial virus (RSV) RNA polymerase inhibitors. The antiviral activity and spectrum of this class was significantly improved by exploring the amino substitution of the pyridine ring, resulting in the discovery of the most potent RSV A polymerase inhibitors reported to date.
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