Artigo Revisado por pares

Discovery of a potent respiratory syncytial virus RNA polymerase inhibitor

2013; Elsevier BV; Volume: 23; Issue: 24 Linguagem: Inglês

10.1016/j.bmcl.2013.10.018

ISSN

1464-3405

Autores

Hui Xiong, Melinda A. Foulk, Lisa Aschenbrenner, Jun Fan, Choi-Lai Tiong-Yip, Kenneth D. Johnson, Demetri T. Moustakas, Paul Fleming, Dean G. Brown, Minli Zhang, Douglas Ferguson, Dedong Wu, Qin Yu,

Tópico(s)

Viral Infections and Immunology Research

Resumo

Targeting viral polymerases has been a proven and attractive strategy for antiviral drug discovery. Herein we describe our effort in improving the antiviral activity and physical properties of a series of benzothienoazepine compounds as respiratory syncytial virus (RSV) RNA polymerase inhibitors. The antiviral activity and spectrum of this class was significantly improved by exploring the amino substitution of the pyridine ring, resulting in the discovery of the most potent RSV A polymerase inhibitors reported to date.

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