Artigo Revisado por pares

Erhöhung der αvβ3‐Selektivität des Angiogenese hemmenden Wirkstoffs Cilengitid durch N‐Methylierung

2011; Wiley; Volume: 123; Issue: 40 Linguagem: Alemão

10.1002/ange.201102971

ISSN

1521-3757

Autores

Carlos Mas‐Moruno, Johannes Beck, Lucas Doedens, Andreas O. Frank, Luciana Marinelli, Sandro Cosconati, Ettore Novellino, Horst Kessler,

Tópico(s)

Coagulation, Bradykinin, Polyphosphates, and Angioedema

Resumo

Angewandte ChemieVolume 123, Issue 40 p. 9668-9672 Zuschrift Erhöhung der αvβ3-Selektivität des Angiogenese hemmenden Wirkstoffs Cilengitid durch N-Methylierung† Dr. Carlos Mas-Moruno, Dr. Carlos Mas-Moruno Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland)Search for more papers by this authorJohannes G. Beck, Johannes G. Beck Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland)Search for more papers by this authorDr. Lucas Doedens, Dr. Lucas Doedens Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland)Search for more papers by this authorDr. Andreas O. Frank, Dr. Andreas O. Frank Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland)Search for more papers by this authorProf. Dr. Luciana Marinelli, Prof. Dr. Luciana Marinelli Dipartimento di Chimica Farmaceutica e Tossicologica, Universitá di Napoli “Federico II”, 80131 Napoli (Italien)Search for more papers by this authorDr. Sandro Cosconati, Dr. Sandro Cosconati Dipartimento di Chimica Farmaceutica e Tossicologica, Universitá di Napoli “Federico II”, 80131 Napoli (Italien)Search for more papers by this authorProf. Dr. Ettore Novellino, Prof. Dr. Ettore Novellino Dipartimento di Chimica Farmaceutica e Tossicologica, Universitá di Napoli “Federico II”, 80131 Napoli (Italien)Search for more papers by this authorProf. Dr. Horst Kessler, Corresponding Author Prof. Dr. Horst Kessler kessler@tum.de Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland) Chemistry Department, Faculty of Science, King Abdulaziz University, 21589 Jeddah (Saudi-Arabien)Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland)Search for more papers by this author Dr. Carlos Mas-Moruno, Dr. Carlos Mas-Moruno Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland)Search for more papers by this authorJohannes G. Beck, Johannes G. Beck Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland)Search for more papers by this authorDr. Lucas Doedens, Dr. Lucas Doedens Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland)Search for more papers by this authorDr. Andreas O. Frank, Dr. Andreas O. Frank Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland)Search for more papers by this authorProf. Dr. Luciana Marinelli, Prof. Dr. Luciana Marinelli Dipartimento di Chimica Farmaceutica e Tossicologica, Universitá di Napoli “Federico II”, 80131 Napoli (Italien)Search for more papers by this authorDr. Sandro Cosconati, Dr. Sandro Cosconati Dipartimento di Chimica Farmaceutica e Tossicologica, Universitá di Napoli “Federico II”, 80131 Napoli (Italien)Search for more papers by this authorProf. Dr. Ettore Novellino, Prof. Dr. Ettore Novellino Dipartimento di Chimica Farmaceutica e Tossicologica, Universitá di Napoli “Federico II”, 80131 Napoli (Italien)Search for more papers by this authorProf. Dr. Horst Kessler, Corresponding Author Prof. Dr. Horst Kessler kessler@tum.de Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland) Chemistry Department, Faculty of Science, King Abdulaziz University, 21589 Jeddah (Saudi-Arabien)Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie, Technische Universität München, 85747 Garching (Deutschland)Search for more papers by this author First published: 25 August 2011 https://doi.org/10.1002/ange.201102971Citations: 11 † Diese Arbeit wurde durch die International Graduate School of Science and Engineering gefördert. Wir danken B. Cordes für technische Hilfe bei der Massenspektrometrie. C.M.M. thanks the Generalitat de Catalunya für ein Beatriu de Pinós-Stipendium. J.G.B dankt der TUM Graduate School für Unterstützung. Read the full textAboutPDF ToolsRequest permissionAdd to favorites ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Feine Unterscheidung: Strukturänderungen durch Amidbindungsmethylierung verbessern die Selektivität des Angiogenese hemmenden Wirkstoffs Cilengitid, der nach N-Methylierung an bestimmten Positionen zwischen den eng verwandten pro-angiogenetischen Integrinen αvβ3 und αvβ5 unterscheiden kann. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description ange_201102971_sm_miscellaneous_information.pdf1.3 MB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume123, Issue40September 26, 2011Pages 9668-9672 This is the German version of Angewandte Chemie. Note for articles published since 1962: Do not cite this version alone. Take me to the International Edition version with citable page numbers, DOI, and citation export. We apologize for the inconvenience. RelatedInformation

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