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Catatonia induced in the rabbit by intracerebral injection of bradykinin and morphine

1971; Elsevier BV; Volume: 15; Issue: 2 Linguagem: Inglês

10.1016/0014-2999(71)90171-3

1879-0712

Glaci R. Da Silva, M. ROCHA E SILVA,

Coordination Chemistry and Organometallics

Bradykinin (BK) in doses of 2.5–5.0 μg, induced catatonia when injected either into the cerebral ventricles or into the cisterna magna of rabbits. In a dose that did not produce catatonia, morphine significantly increased the duration of catatonia induced by BK. The probable site of action for BK-induced catatonia is suggested. The potentiation of BK central effects by small doses of morphine suggests the possibility that the alkaloid produces its central effects through a kininergic mechanism. A special device to measure catatonia is also described.