Biosynthesis of a Vasotocin-Like Peptide in Cell Cultures from Pineal Glands of Human Fetuses
1973; American Association for the Advancement of Science; Volume: 181; Issue: 4106 Linguagem: Inglês
10.1126/science.181.4106.1252
ISSN1095-9203
AutoresS. Pavel, M. Dorcescu, R Petrescu-Holban, E Ghinea,
Tópico(s)Protein Hydrolysis and Bioactive Peptides
ResumoCultured cells from pineal glands of human fetuses release into their media a substance that has antidiuretic and hydroosmotic activities. The ratio of these activities as well as their susceptibility to tryptic digestion, specific oxidative inactivation by tyrosinase, and reductive inactivation by sodium thioglycollate, indicates the presence of a basic peptide, presumably identical with arginine vasotocin. The total amount of this peptide released into the culture media during 38 days of incubation is about ten times greater than the amount contained in nonincubated pineal glands from fetuses of the same age, strongly suggesting that fetal ependymal cells from the pineal gland can synthesize in vitro a peptide similar to arginine vasotocin.
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