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Efficacy and Tolerability of Topical 1% Cidofovir Cream for the Treatment of External Anogenital Warts in HIV-Infected Persons

2001; Lippincott Williams & Wilkins; Volume: 28; Issue: 6 Linguagem: Inglês

10.1097/00007435-200106000-00007

1537-4521

Alberto Matteelli, Anna Beltrame, S Graifemberghi, Maria Antonietta Forleo, Maurizio Gulletta, Giuseppe Ciravolo, S Tedoldi, Caterina Casalini, Giampiero Carosi,

Parvovirus B19 Infection Studies

Treatment options for anogenital warts in patients with HIV-1 are unsatisfactory because they fail to eradicate latent human papillomavirus.To determine tolerability and efficacy of topical 1% cidofovir cream for the treatment of external anogenital warts in HIV-infected patients.A randomized, placebo-controlled, single-blind, crossover pilot study of either 1% cidofovir cream or placebo applied once daily 5 days a week for 2 weeks followed by 2 weeks of observation was performed.Six patients were randomized to 1% cidofovir cream and six to placebo. The latter patients eventually received 1% cidofovir cream. Thus, 12 treatment rounds of cidofovir were compared with six rounds of placebo. A reduction of more than 50% in the total wart area achieved by seven cidofovir treatments (58%), as compared with no placebo regimen (P = 0.02). Local reactions occurred in 10 of the 12 patients treated with cidofovir, as compared with 0 of the 6 subjects in the placebo group (P < 0.001).For the initial clearance of anogenital warts in HIV-infected patients, 1% cidofovir cream is significantly more effective than vehicle cream. Local mucosal erosion is a common side effect.