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Interleukin‐6 (IL‐6) functions as an in vitro autocrine growth factor in renal cell carcinomas

1989; Wiley; Volume: 250; Issue: 2 Linguagem: Inglês

10.1016/0014-5793(89)80805-1

1873-3468

Shunji Miki, Masayuki Iwano, Yoshitsugu Miki, Masahiro Yamamoto, Bo Tang, Kiyoshi Yokokawa, Takao Sonoda, Toshio Hirano, Tadamitsu Kishimoto,

Monoclonal and Polyclonal Antibodies Research

Interleukin-6 (IL-6) was found to be a growth factor of renal cell carcinomas Furthermore, renal cell carcinomas freshly isolated from the patients expressed mRNA of IL-6 and secreted biologically active IL-6 under the culture conditions where the tumor cells could grow, but they did not produce IL-6 nor proliferate in the absence of fetal calf serum. The production of IL-6 by the tumor cells was also demonstrated by immunostaining of the IL-6-producing cells utilizing anti-IL-6 antiserum. Moreover, anti-IL-6 antiserum specifically inhibited the in vitro tumor growth. All data indicated that IL-6 functions as an in vitro autocrine growth factor of renal cell carcinomas.