A Comparison of Propofol- and Dexmedetomidine-induced Electroencephalogram Dynamics Using Spectral and Coherence Analysis
2014; Lippincott Williams & Wilkins; Volume: 121; Issue: 5 Linguagem: Inglês
10.1097/aln.0000000000000419
ISSN1528-1175
AutoresOluwaseun Akeju, Kara J. Pavone, M. Brandon Westover, Rafael Vázquez, Michael J. Prerau, P. Grace Harrell, Katharine E. Hartnack, James Rhee, Aaron L. Sampson, Kathleen Habeeb, Lei Gao, Eric T. Pierce, J. Walsh, Emery N. Brown, Patrick L. Purdon,
Tópico(s)Analytical Chemistry and Sensors
ResumoElectroencephalogram patterns observed during sedation with dexmedetomidine appear similar to those observed during general anesthesia with propofol. This is evident with the occurrence of slow (0.1 to 1 Hz), delta (1 to 4 Hz), propofol-induced alpha (8 to 12 Hz), and dexmedetomidine-induced spindle (12 to 16 Hz) oscillations. However, these drugs have different molecular mechanisms and behavioral properties and are likely accompanied by distinguishing neural circuit dynamics.
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