Portal de Periódicos da CAPES

Decorin causes autophagy in endothelial cells via Peg3

2013; National Academy of Sciences; Volume: 110; Issue: 28 Linguagem: Inglês

10.1073/pnas.1305732110

1091-6490

Simone Buraschi, Thomas Neill, Atul Kumar Goyal, Chiara Poluzzi, James Smythies, Rick T. Owens, Liliana Schaefer, Annabel Torres, Renato V. Iozzo,

Cancer-related gene regulation

Significance We identified a function for a member of the extracellular matrix in the regulation of autophagy. Decorin, a member of the small leucine-rich proteoglycan family and an established pan-receptor tyrosine kinase inhibitor, evokes endothelial cell autophagy and inhibits angiogenesis. This process is mediated by a high-affinity interaction with VEGFR2 which leads to increased levels of Peg3, a tumor-suppressor gene. We provide mechanistic evidence that Peg3 is required to maintain basal levels of Beclin 1, a major autophagic marker. These data provide a paradigmatic shift for other soluble matrix constituents to regulate autophagy.