Acute febrile neutrophilic dermatosis (Sweet-s syndrome) and myeloproliferative disorders
1983; Wiley; Volume: 51; Issue: 8 Linguagem: Inglês
10.1002/1097-0142(19830415)51
ISSN1097-0142
AutoresPhilip H. Cooper, Donald J. Innes, Kenneth E. Greer,
Tópico(s)Autoimmune Bullous Skin Diseases
ResumoCancerVolume 51, Issue 8 p. 1518-1526 ArticleFree Access Acute febrile neutrophilic dermatosis (Sweet-s syndrome) and myeloproliferative disorders Philip H. Cooper MD, Corresponding Author Philip H. Cooper MD Departments of Pathology and Dermatology, University of Virginia, CharlottesvilleDepartment of Pathology, Box 214, University of Virginia Medical Center, Charlottesville, VA 22908===Search for more papers by this authorDonald J. Innes Jr. MD, Donald J. Innes Jr. MD Departments of Pathology and Dermatology, University of Virginia, CharlottesvilleSearch for more papers by this authorKenneth E. Greer MD, Kenneth E. Greer MD Departments of Pathology and Dermatology, University of Virginia, CharlottesvilleSearch for more papers by this author Philip H. Cooper MD, Corresponding Author Philip H. Cooper MD Departments of Pathology and Dermatology, University of Virginia, CharlottesvilleDepartment of Pathology, Box 214, University of Virginia Medical Center, Charlottesville, VA 22908===Search for more papers by this authorDonald J. Innes Jr. MD, Donald J. Innes Jr. MD Departments of Pathology and Dermatology, University of Virginia, CharlottesvilleSearch for more papers by this authorKenneth E. Greer MD, Kenneth E. Greer MD Departments of Pathology and Dermatology, University of Virginia, CharlottesvilleSearch for more papers by this author First published: 15 April 1983 https://doi.org/10.1002/1097-0142(19830415)51:8 3.0.CO;2-UCitations: 144AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Acute febrile neutrophilic dermatosis (ND) consists of the abrupt onset of red, tender, cutaneous plaques on the face, extremities, and upper trunk, accompanied by fever, malaise, and neutrophilic leukocytosis. Histologically, there are distinctive, dense, dermal infiltrates of neutrophils. Response to systemic steroids is dramatic. This report describes four patients with leukemia or preleukemia and ND (LND), reviews reports of 12 similar patients, and compares LND with ND in otherwise healthy individuals (idiopathic ND, IND). Although lesions of LND more frequently had vesiculobullous appearances or location on mucous membranes, this study showed no consistent difference between LND and IND with regard to cutaneous signs, symptoms, histologic findings, and response to therapy. The first episode of LND either preceded or followed documentation of the myeloproliferative disorder, and the most common associated hematologic conditions were acute myeloid or myelomonocytic leukemia. Moderate to severe anemia was present in nine of ten patients whose first episode of LND preceded the discovery of the hematologic condition by eights months or less. The presence of anemia is the most obvious and readily detectable difference between LND and IND. 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