Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

The effects of catalase inhibition into the fourth cerebral ventricle on the Bezold-Jarisch reflex in spontaneously hypertensive rats

2011; Imperial College Press; Volume: 10; Issue: 04 Linguagem: Inglês

10.1142/s021963521100283x

1757-448X

José R Cisternas, Vítor Engrácia Valenti, Mônica Akemi Sato, Fernando Luiz Affonso Fonseca, Paulo Hilário Nascimento Saldiva, Carlos Bandeira de Mello Monteiro, Modesto Leite Rolim Neto, Luciano Miller Reis Rodrigues, Luíz Carlos de Abreu,

Neuroscience of respiration and sleep

Journal of Integrative NeuroscienceVol. 10, No. 04, pp. 475-487 (2011) ArticlesNo AccessThe effects of catalase inhibition into the fourth cerebral ventricle on the Bezold-Jarisch reflex in spontaneously hypertensive ratsJosé Raul Cisternas, Vitor E. Valenti, Monica A. Sato, Fernando L. A. Fonseca, Paulo H. N. Saldiva, Carlos B. De Mello Monteiro, Modesto Leite Rolim Neto, Luciano M. R. Rodrigues, and Luiz Carlos De AbreuJosé Raul CisternasLaboratório de Escrita Científica, Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, BrasilCorresponding author., Vitor E. ValentiLaboratório de Escrita Científica, Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, BrasilDepartamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil, Monica A. SatoLaboratório de Escrita Científica, Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil, Fernando L. A. FonsecaLaboratório de Escrita Científica, Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil, Paulo H. N. SaldivaDepartamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil, Carlos B. De Mello MonteiroEscola de Artes, Ciência e Humanidades da Universidade de São Paulo, São Paulo, SP, Brasil, Modesto Leite Rolim NetoUniversidade Federal do Ceará Cariri, CE, Brasil, Luciano M. R. RodriguesLaboratório de Escrita Científica, Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brasil, and Luiz Carlos De AbreuLaboratório de Escrita Científica, Departamento de Morfologia e Fisiologia, Faculdade de Medicina do ABC, Santo André, SP, Brasilhttps://doi.org/10.1142/S021963521100283XCited by:3 PreviousNext AboutSectionsPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsRecommend to Library ShareShare onFacebookTwitterLinked InRedditEmail AbstractMany studies have investigated the role of oxidative stress on cardiovascular system in the brainstem of spontaneously hypertensive rats (SHR). However, we do not know yet if catalase inhibition influences cardiopulmonary reflex (Bezol-Jarisch reflex). Thus, we aimed to evaluate the effects of central catalase inhibition on cardiopulmonary reflex in SHR. Males Wistar Kyoto (WKY) rats and SHR were implanted with a stainless steel guide cannula into the fourth cerebral ventricle (4th V). The femoral artery and vein were cannulated for mean arterial pressure (MAP) and heart rate (HR) measurement and drug infusion, respectively. The cardiopulmonary reflex was tested with phenylbiguanide (PBG, 8 μg/kg, bolus, i.v.). Cardiopulmonary reflex was evaluated before and 15 minutes after 3-amino-1,2,4-triazole (ATZ, 0.01 g/100 μL) injection into the 4th V. Vehicle treatment did not change basal MAP and HR and cardiopulmonary reflex responses in SHR and WKY rats. Central ATZ increased hypotensive (p = 0.038) responses without influencing the bradycardic reflex (p = 0.287) in WKY rats. In SHR, ATZ increased hypotension (p = 0.0004) and bradycardic (p = 0.04) responses to i.v. PBG. No changes were observed regarding basal MAP and HR after ATZ injection in SHR and WKY rats. We suggest central catalase inhibition affects cardiopulmonary reflex with more intensity in SHR compared to WKY rats.Keywords:Reflexoxidative stresscatalasemedulla oblongatacardiovascular systemreflexhydrogen peroxide References M. Akay, K. L. Moodie and P. J. Hoopes, J. Integr. Neurosci 5, 417 (2006). Medline, Google ScholarN. Ardanaz, W. H. Beierwaltes and P. J. Pagano, Pharmacol. Rep. 60, 61 (2008). Medline, ISI, Google ScholarR. J. Barry, Acta. Neurobiol. Exp. 56, 469 (1996). Medline, ISI, Google ScholarM. Bertagnolliet al., J. Hypertens. 24, 2437 (2006), DOI: 10.1097/01.hjh.0000251905.08547.17. Crossref, Medline, ISI, Google ScholarN. S. Bissoliet al., Pharmacol. Res. 59, 379 (2009), DOI: 10.1016/j.phrs.2009.03.001. Crossref, Medline, ISI, Google ScholarL. M. Cardosoet al., Brain. Res. Bull. 71, 37 (2006), DOI: 10.1016/j.phrs.2009.03.001. Crossref, Medline, ISI, Google ScholarL. M. Cardosoet al., Am. J. Physiol. Regul. Integr. Comp. Physiol. 297, R462 (2009), DOI: 10.1152/ajpregu.90796.2008. Crossref, Medline, ISI, Google ScholarS. H. H. Chanet al., Hypertension 53, 217 (2009), DOI: 10.1161/HYPERTENSIONAHA.108.116905. Crossref, Medline, ISI, Google ScholarJ. R. Cisternaset al., Int. Arch. Med. 3, 2 (2010), DOI: 10.1186/1755-7682-3-2. Crossref, Medline, Google ScholarE. Colombariet al., Hypertension 38, 549 (2001), DOI: 10.1186/1755-7682-3-2. Crossref, Medline, ISI, Google ScholarJ. P. Fluckigeret al., Eur. J. Pharmacol. 109, 105 (1985), DOI: 10.1016/0014-2999(85)90545-X. Crossref, Medline, ISI, Google ScholarG. Grassiet al., Hypertension 12, 227 (1988), DOI: 10.1016/0014-2999(85)90545-X. Crossref, Medline, ISI, Google ScholarY. Hirooka, Auton. Neurosci. 126, 120 (2006). Medline, ISI, Google ScholarY. Hirookaet al., Hypertens. Res. 29, 49 (2006). Crossref, Medline, ISI, Google ScholarA. Jarisch and Y. Zotterman, Acta Physiol. Scand. 16, 31 (1948). Crossref, Google ScholarS. Kimoto-Kinoshita, S. Nishida and T. T. Tomura, Neurosci. Lett. 273, 41 (1999), DOI: 10.1016/S0304-3940(99)00623-0. Crossref, Medline, ISI, Google ScholarT. Kishiet al., Circulation 109, 2357 (2004), DOI: 10.1161/01.CIR.0000128695.49900.12. Crossref, Medline, ISI, Google ScholarY. Kogaet al., Hypertens. Res. 31, 2075 (2008), DOI: 10.1291/hypres.31.2075. Crossref, Medline, ISI, Google Scholar G. Paxinos and C. Watson , The Rat Brain in Stereotaxic Coordinates , 2nd edn. ( Academic Press , Sydney, NSW , 1997 ) . Google ScholarV. M. Pokrovskii, J. Integr. Neurosci. 4, 161 (2005). Link, Google ScholarO. Sorget al., Mol. Med. 3, 431 (1997). Crossref, Medline, ISI, Google ScholarM. H. Taiet al., Free Radic. Biol. Med. 38, 450 (2005), DOI: 10.1016/j.freeradbiomed.2004.11.015. Crossref, Medline, ISI, Google ScholarA. Takahashi, M. Mikami and J. Yang, Eur. J. Neurosci. 25, 705 (2007), DOI: 10.1111/j.1460-9568.2007.05323.x. Crossref, Medline, ISI, Google ScholarP. Thorén, E. Noresson and S. E. Ricksten, Acta Physiol. Scand. 107, 13 (1979), DOI: 10.1111/j.1460-9568.2007.05323.x. Crossref, Medline, Google ScholarM. Ursino and E. Magosso, J. Integr. Neurosci. 2, 219 (2003). Link, Google ScholarV. E. Valentiet al., Arq. Bras. Cardiol. 92, 205 (2009), DOI: 10.1590/S0066-782X2009000300009. Medline, ISI, Google ScholarV. E. Valentiet al., Clin. Invest. Med. 32, E251 (2009), DOI: 10.1590/S0066-782X2009000300009. Crossref, Medline, ISI, Google ScholarV. E. Valentiet al., Int. J. Environ. Health. Res. 20, 431 (2010), DOI: 10.1080/09603123.2010.491852. Crossref, Medline, ISI, Google ScholarV. E. Valentiet al., Clinics 65, 1339 (2010), DOI: 10.1590/S1807-59322010001200018. Crossref, Medline, ISI, Google ScholarV. E. Valentiet al., Clinics 65, 203 (2010), DOI: 10.1590/S1807-59322010000200013. Crossref, Medline, ISI, Google ScholarV. E. Valentiet al., Cardiovasc. J. Afr. 22, 14 (2011), DOI: 10.1590/S1807-59322010000200013. Medline, ISI, Google ScholarV. E. Valenti, L. C. Abreu and C. Ferreira, Arq. Bras. Cardiol. 96, 148 (2011), DOI: 10.1590/S0066-782X2010005000164. Crossref, Medline, ISI, Google ScholarV. E. Valentiet al., J. Integr. Neurosci. 10, 1 (2011), DOI: 10.1590/S0066-782X2010005000164. Link, ISI, Google ScholarV. E. Valentiet al., J Integr Neurosci 10, 161 (2011). Link, ISI, Google ScholarH. Wakiet al., Auton. Neurosci. 142, 25 (2008), DOI: 10.1016/j.autneu.2008.07.003. Crossref, Medline, ISI, Google ScholarH. Wakiet al., Auton. Neurosci. 142, 40 (2008), DOI: 10.1016/j.autneu.2008.07.001. Crossref, Medline, ISI, Google ScholarJ. Zanzinger, Auton. Neurosci. 98, 24 (2002), DOI: 10.1016/S1566-0702(02)00025-5. Crossref, Medline, ISI, Google Scholar FiguresReferencesRelatedDetailsCited By 3Slow breathing influences cardiac autonomic responses to postural maneuverGiovanna Ana de Paula Vidigal, Bruna S. Tavares, David M. Garner, Andrey A. Porto and Luiz Carlos de Abreu et al.1 May 2016 | Complementary Therapies in Clinical Practice, Vol. 23Resposta aguda do sistema nervoso autônomo a diferentes estímulos auditivos musicais em mulheresLucas Lima Ferreira, Carlos Marques Vanderlei and Vitor Engrácia Valenti30 September 2015 | Revista Neurociências, Vol. 23, No. 3Effects of the administration of a catalase inhibitor into the fourth cerebral ventricle on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smokeVitor E. Valenti, Luiz Carlos de Abreu, Fernando L.A. Fonseca, Fernando Adami and Monica A. Sato et al.1 Jun 2013 | Clinics, Vol. 68, No. 6 Recommended Vol. 10, No. 04 Metrics History Received 16 July 2011 Accepted 19 September 2011 KeywordsReflexoxidative stresscatalasemedulla oblongatacardiovascular systemreflexhydrogen peroxidePDF download